Southern Region

The oldest city in Arizona, Tucson, lies in Southern Arizona. It is home to spectacular varieties of cacti, particularly abundant in Saguaro National Park, and Organ Pipe Cactus National Monument. Recreational areas include Sabino Canyon, Cochise Stronghold, and Chiricahua National Park. Its Colossal Cave was a hideout for outlaws, and Tombstone was the town "too tough to die".

The Southern region includes the counties of Cochise, Pima, and Santa Cruz.